I had already managed to get claude-science running in a container, and basic functionality worked without major issues. But when I wanted to do things like molecular docking, I couldn’t—the container simply had no GPU. However, when I pulled NVIDIA’s official image to build the container the same way I had before, something bizarre happened: every language kernel in CS—Python, Perl, R—stopped working, and the entire runtime environment was rendered useless.
This was truly beyond my understanding. After consulting Gemini manually with no luck, I decided to let opencode + deepseek-v4-flash handle it on its own—not me remotely typing commands and directing it, but an AI agent living inside the container that read the logs, bisected parameters, decompiled the parser, and edited the entrypoint itself. It was a strange and interesting experience; here’s a record of it.