In bioinformatics, the more cutting-edge your research direction, the more problems you’ll face from the informatics side. Even when papers are published with excellent results, and the original authors share their code or even provide ready-to-use software tools, it doesn’t mean we can easily use these existing resources for reproduction or further research. Chaotic environment setup is just one aspect - more often than not, since software authors aren’t professional software engineers, we should be grateful if the tool just works. We can’t expect these software to be bug-free, nor can we expect them to have decent performance (unless performance was a development goal). Even tools from well-established labs aren’t free to these issues, such as… Azimuth.