In cancer research, comparing genomic features between tumor samples and organoid models is crucial for validating model reliability. Circos plots provide an intuitive way to visualize detected mutations across the genome, making them commonly used for representing overall detection results of representative samples. While reading the circlize documentation, I came across an example demonstrating paired samples, which I found suitable for showcasing paired primary samples and organoids. I’ve adapted it to create a plot for displaying paired samples. The code is primarily based on the official documentation’s 9.5 Concatenating two genomes